Metformin

mechanistic target of rapamycin kinase ; Homo sapiens







361 Article(s)
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301 24009772 Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts. 2013 1
302 24180199 [Metformin, an antidiabetic molecule with anti-cancer properties]. 2013 Sep 1
303 24335168 Metformin inhibits esophagus cancer proliferation through upregulation of USP7. 2013 1
304 24351837 The antidiabetic drug metformin inhibits the proliferation of bladder cancer cells in vitro and in vivo. 2013 Dec 18 3
305 22080879 LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells. 2012 Jan 2
306 22252099 Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. 2012 May 3
307 22343549 Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake. 2012 2
308 22378068 Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. 2012 Mar 1 3
309 22389381 Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells. 2012 Jun 2
310 22406476 Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. 2012 Jun 1
311 22443173 Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. 2012 Mar 26 2
312 22469973 Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway. 2012 Jun 3
313 22490993 Does use of metformin protect against cancer in Type 2 diabetes mellitus? 2012 Feb 1
314 22500211 Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells. 2012 2
315 22540890 Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway. 2012 Sep-Oct 3
316 22593441 Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro. 2012 May 1
317 22611195 Distinct perturbation of the translatome by the antidiabetic drug metformin. 2012 Jun 5 2
318 22659796 Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells. 2012 Jun 15 1
319 22735790 Metformin impairs the growth of liver kinase B1-intact cervical cancer cells. 2012 Oct 2
320 22863784 Effect of advanced glycation end products on lectin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells. 2012 1
321 22994747 Metformin inhibits growth of hepatocellular carcinoma cells by inducing apoptosis via mitochondrion-mediated pathway. 2012 1
322 23151022 In vitro and in vivo anti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma. 2012 Nov 14 1
323 23525940 One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin. 2012 Dec 1
324 21084384 Interaction of glibenclamide and metformin at the level of translation in pancreatic β cells. 2011 Feb 4
325 21168492 Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin (mTOR) in endometrial cancer cells. 2011 Sep 2
326 21262823 Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. 2011 Feb 8 1
327 21270604 Metformin reverses progestin resistance in endometrial cancer cells by downregulating GloI expression. 2011 Feb 2
328 21349801 Metformin: its emerging role in oncology. 2011 Jan-Mar 1
329 21465524 Metformin sensitizes insulin signaling through AMPK-mediated PTEN down-regulation in preadipocyte 3T3-L1 cells. 2011 May 2
330 21470407 Understanding the benefit of metformin use in cancer treatment. 2011 Apr 6 2
331 21532889 Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. 2011 May 1
332 21540236 Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. 2011 Jul 1 4
333 21552292 Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation. 2011 Jul 2
334 21631893 Metformin as an antitumor agent in cancer prevention and treatment. 2011 Dec 2
335 21655990 Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. 2011 Aug 1
336 21680296 Metformin: a new option in cancer treatment. 2011 Jun 2
337 21840335 Caloric restriction. 2011 Jun 1
338 22015290 Obesity and insulin resistance in breast cancer--chemoprevention strategies with a focus on metformin. 2011 Oct 1
339 22021366 Antileukemic effects of AMPK activators on BCR-ABL-expressing cells. 2011 Dec 8 1
340 22067284 Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling. 2011 Oct 2
341 22203527 Metformin: multi-faceted protection against cancer. 2011 Dec 1
342 19822355 Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy. 2010 Jan 1
343 20126541 Metabolic regulation of neuronal plasticity by the energy sensor AMPK. 2010 Feb 1 1
344 20135346 Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. 2010 Aug 2
345 20363874 AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. 2010 Jun 2
346 20465505 Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin. 2010 May 1
347 20564343 Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. 2010 Jul 1
348 20668229 The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. 2010 Nov 18 2
349 20810671 Chemoprevention meets glucose control. 2010 Sep 1
350 21098287 Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. 2010 Dec 14 1