Metformin

mechanistic target of rapamycin kinase ; Homo sapiens







361 Article(s)
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Title
Pub. Year
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351 19106626 The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells. 2009 Jan 1 2
352 19560877 Is it the time for metformin to take place in adjuvant treatment of Her-2 positive breast cancer? Teaching new tricks to old dogs. 2009 Oct 1
353 19574203 mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb). 2009 Jul 1
354 19679549 Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth. 2009 Aug 15 1
355 19858366 LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin. 2009 Dec 1 1
356 19858375 If mammalian target of metformin indirectly is mammalian target of rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in cancer clinical trials. 2009 Nov 20 2
357 18678646 A gene signature-based approach identifies mTOR as a regulator of p73. 2008 Oct 1
358 18803638 Metformin suppresses intestinal polyp growth in ApcMin/+ mice. 2008 Nov 1
359 17698034 Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. 2007 Oct 12 1
360 18006825 Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. 2007 Nov 15 5
361 16354680 Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. 2006 Jan 1