Pub. Date : 2012 Mar 1
PMID : 22378068
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Metformin-induced AMPK activation was associated with the inhibition of the mTOR signaling without involving AKT. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Moreover, lymphoma cell response to the chemotherapeutic agent doxorubicin and mTOR inhibitor temsirolimus was significantly enhanced when co-treated with metformin. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |