Pub. Date : 2013 Dec 18
PMID : 24351837
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further experiments revealed that metformin activated AMP-activated protein kinase (AMPK) and suppressed mammalian target of rapamycin (mTOR), the central regulator of protein synthesis and cell growth. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Further experiments revealed that metformin activated AMP-activated protein kinase (AMPK) and suppressed mammalian target of rapamycin (mTOR), the central regulator of protein synthesis and cell growth. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Moreover, daily treatment of metformin led to a substantial inhibition of tumor growth in a xenograft model with concomitant decrease in the expression of proliferating cell nuclear antigen (PCNA), cyclin D1 and p-mTOR. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |