Title : Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.

Pub. Date : 2010 Aug

PMID : 20135346






2 Functional Relationships(s)
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1 Adenosine 5"- monophosphate-activated protein kinase (AMPK) activators such as metformin have similar actions, in keeping with the TSC2/1 pathway linking activation of AMPK to inhibition of mTOR. Metformin mechanistic target of rapamycin kinase Homo sapiens
2 Although both rapamycin and metformin inhibit mTOR (the former directly and the latter through AMPK signaling), our results demonstrate previously unrecognized differences between these agents. Metformin mechanistic target of rapamycin kinase Homo sapiens