pregna-4,17-diene-3,16-dione

nuclear receptor subfamily 1 group H member 4 ; Homo sapiens







25 Article(s)
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1 35278405 Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease via regulating FXR/SHP/SREBP-1c axis. 2022 Apr 15 1
2 33488300 Z-Guggulsterone Induces Apoptosis in Gastric Cancer Cells through the Intrinsic Mitochondria-Dependent Pathway. 2021 2
3 34091148 Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism. 2021 Jul 1
4 32534360 Ethyl acetate extract of herpetospermum pedunculosum alleviates α-naphthylisothiocyanate-induced cholestasis by activating the farnesoid x receptor and suppressing oxidative stress and inflammation in rats. 2020 Jun 2 1
5 32846898 Farnesoid X Receptor Activation Stimulates Organic Cations Transport in Human Renal Proximal Tubular Cells. 2020 Aug 24 2
6 30747230 Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR/NF-κB signalling pathway. 2019 Mar 1
7 30844798 Chenodeoxycholic Acid Releases Proinflammatory Cytokines from Small Intestinal Epithelial Cells Through the Farnesoid X Receptor. 2019 1
8 31673308 Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool. 2019 Aug 1 3
9 29761098 Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening. 2018 1
10 28970500 The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway. 2017 Oct 2 1
11 27773686 Differential modulation of FXR activity by chlorophacinone and ivermectin analogs. 2016 Dec 15 1
12 28066584 Overexpression of farnesoid X receptor in small airways contributes to epithelial to mesenchymal transition and COX-2 expression in chronic obstructive pulmonary disease. 2016 Nov 1
13 26098428 Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes. 2015 1
14 24953769 Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone. 2014 Sep 2
15 23119029 Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis. 2012 1
16 21364590 Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion. 2011 Mar 15 2
17 21893226 Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts. 2011 Dec 2
18 19102680 Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia. 2009 Jan 1
19 18510604 Bile acid-stimulated expression of the farnesoid X receptor enhances the immune response in Barrett esophagus. 2008 Jun 1
20 17135343 The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism. 2007 Mar 3
21 16439808 Lipids isolated from bone induce the migration of human breast cancer cells. 2006 Apr 1
22 17054793 Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro. 2006 Oct 20 1
23 15817812 Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes. 2005 Aug 1
24 12525500 Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. 2003 Mar 21 1
25 12705905 Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene. 2003 Apr 25 2