Pub. Date : 2019 Aug 1
PMID : 31673308
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool. | pregna-4,17-diene-3,16-dione | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
| 2 | Although relatively weak, its activity at the farnesoid X receptor (FXR) is particularly intriguing as guggulsterone acts as an antagonist with a peculiar ability of gene selective modulation. | pregna-4,17-diene-3,16-dione | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
| 3 | We report here a chemical biology study with the aim to further characterize the biological action of guggulsterone at the FXR and to obtain further insights into the functional role played by noncanonical FXR binding pockets S2 and S3. | pregna-4,17-diene-3,16-dione | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |