Title : Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.

Pub. Date : 2016 Dec 15

PMID : 27773686






1 Functional Relationships(s)
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1 (Z)-Guggulsterone, chlorophacinone, ivermectin, and their analogs were profiled for their ability to alter CDCA-mediated FXR binding using a panel of 154 coregulator motifs and to induce or inhibit transactivation and coactivator recruitment activities of constitutive androstane receptor (CAR), liver X receptor alpha (LXRalpha), or pregnane X receptor (PXR). pregna-4,17-diene-3,16-dione nuclear receptor subfamily 1 group H member 4 Homo sapiens