Title : Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening.

Pub. Date : 2018

PMID : 29761098






1 Functional Relationships(s)
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1 Compared to the control compound guggulsterone (IC50 = 6.47 muM), compounds 2a and 3a displayed 5- and 3-fold higher antagonistic activities against FXR, respectively. pregna-4,17-diene-3,16-dione nuclear receptor subfamily 1 group H member 4 Homo sapiens