Title : Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.

Pub. Date : 2003 Apr 25

PMID : 12705905






2 Functional Relationships(s)
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1 Guggulsterone, a plant sterol that lowers serum cholesterol, has been shown to antagonize FXR activated genes. pregna-4,17-diene-3,16-dione nuclear receptor subfamily 1 group H member 4 Homo sapiens
2 Transient transfection assay of a human BSEP/luciferase reporter in HepG2 cells transfected with FXR reveals that guggulsterone strongly antagonizes bile acid induction of the BSEP gene. pregna-4,17-diene-3,16-dione nuclear receptor subfamily 1 group H member 4 Homo sapiens