Atorvastatin

3-hydroxy-3-methylglutaryl-CoA reductase ; Homo sapiens







125 Article(s)
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51 20712135 Effect of atorvastatin on aldosterone production induced by glucose, LDL or angiotensin II in human renal mesangial cells. 2010 1
52 20714791 Statins attenuate high mobility group box-1 protein induced vascular endothelial activation : a key role for TLR4/NF-κB signaling pathway. 2010 Dec 1
53 20953062 Sympathoinhibition by atorvastatin in hypertensive patients. 2010 Nov 1
54 19067673 (TTA)n polymorphism in 3-hydroxy-3-methylglutaryl-coenzyme A and response to atorvastatin in coronary artery disease patients. 2009 Mar 2
55 19237515 Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. 2009 May 1
56 20069794 Solubility and stability enhancement of atorvastatin by cyclodextrin complexation. 2009 May-Jun 1
57 17651990 Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection. 2008 Jan-Feb 1
58 18261731 The creatine kinase response to eccentric exercise with atorvastatin 10 mg or 80 mg. 2008 Sep 1
59 18303938 Amlodipine/atorvastatin fixed-dose combination: a review of its use in the prevention of cardiovascular disease and in the treatment of hypertension and dyslipidemia. 2008 2
60 18395165 Atorvastatin monotherapy vs. combination therapy in the management of patients with combined hyperlipidemia. 2008 May 1
61 18547436 Plasma PCSK9 levels are significantly modified by statins and fibrates in humans. 2008 Jun 11 1
62 18720283 Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin. 2008 Sep 1
63 17261740 Clinical trials of neuroprotective therapies. 2007 Feb 1
64 17529847 Effect of atorvastatin on progression of sensorineural hearing loss and tinnitus in the elderly: results of a prospective, randomized, double-blind clinical trial. 2007 Jun 1
65 17622571 Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. 2007 Oct 1 4
66 16503719 Modulatory effects of atorvastatin on endothelial cell-derived chemokines, cytokines, and angiogenic factors. 2006 Mar 1
67 16554298 Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin. 2006 Jun 2 1
68 19804188 Atorvastatin: beyond lipid-lowering effects in the diabetic population. 2006 Sep 1
69 15962651 Randomized trial of atorvastatin in improving endothelial function in diabetics without prior coronary disease and having average cholesterol level. 2005 Mar 1
70 16020911 Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins. 2005 1
71 16185099 A new perspective in the treatment of dyslipidemia : can fenofibrate offer unique benefits in the treatment of type 2 diabetes mellitus? 2005 1
72 16284747 Rapid emergence of effect of atorvastatin on cardiovascular outcomes in the Collaborative Atorvastatin Diabetes Study (CARDS). 2005 Dec 1
73 16327254 Lipids and stroke: the opportunity of lipid-lowering treatment. 2005 1
74 16356805 Improved outcome after acute coronary syndromes with an intensive versus standard lipid-lowering regimen: results from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) trial. 2005 Dec 1
75 16356809 A rationale for combination therapy in risk factor management: a mechanistic perspective. 2005 Dec 1
76 16360444 Atorvastatin: a potential chemopreventive agent in bladder cancer. 2005 Dec 1
77 14684313 An efficient synthesis of N3,4-diphenyl-5-(4-fluorophenyl)-2-isopropyl-1H-3-pyrrolecarboxamide, a key intermediate for atorvastatin synthesis. 2004 Jan 5 1
78 15381079 Beta4 integrin is involved in statin-induced endothelial cell death. 2004 Oct 22 1
79 15488897 The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase. 2004 Nov 12 1
80 12612140 Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. 2003 Mar 1
81 12612979 A controlled, prospective study of the effects of atorvastatin on proteinuria and progression of kidney disease. 2003 Mar 1
82 12648031 An economic analysis of the Atorvastatin Comparative Cholesterol Efficacy and Safety Study (ACCESS). 2003 1
83 12816876 Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins. 2003 Sep 1 1
84 12960612 Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. 2003 Sep 1
85 14564679 Effect of atorvastatin on apolipoprotein B48 metabolism and low-density lipoprotein receptor activity in normolipidemic patients with coronary artery disease. 2003 Oct 1
86 14578459 Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells. 2003 Oct 1
87 14687410 Atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces bone resorption in the elderly. 2003 Nov 1
88 11772327 Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia. 2002 Jan 1
89 11831546 Pharmacokinetic and pharmacodynamic assessments of HMG-CoA reductase inhibitors when coadministered with everolimus. 2002 Feb 1
90 11887170 Atorvastatin treatment beneficially alters the lipoprotein profile and increases low-density lipoprotein particle diameter in patients with combined dyslipidemia and impaired fasting glucose/type 2 diabetes. 2002 Mar 1
91 11918754 A placebo-controlled trial examining atorvastatin in dyslipidemic patients undergoing CAPD. 2002 Apr 1
92 12017409 A preliminary evaluation of neural network analysis for pharmacodynamic modeling of the dosing of the hydroxymethylglutaryl coenzyme A-reductase inhibitors simvastatin and atorvastatin. 2002 Apr 1
93 12145183 Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. 2002 Aug 1
94 12181212 Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia. 2002 Sep 1
95 12426205 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. 2002 Nov 1 1
96 12433810 Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. 2002 Dec 1
97 12494218 [Effect of atorvastatin on endothelial function in patients with familial hypercholesterolemia]. 2002 1
98 12769127 Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia. 2002 Mar 1
99 11336625 Atorvastatin. 2001 May 2
100 11474489 Effect of atorvastatin on low-density lipoprotein subtypes in patients with different forms of hyperlipoproteinemia and control subjects. 2001 Aug 1