Title : A preliminary evaluation of neural network analysis for pharmacodynamic modeling of the dosing of the hydroxymethylglutaryl coenzyme A-reductase inhibitors simvastatin and atorvastatin.

Pub. Date : 2002 Apr

PMID : 12017409






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1 OBJECTIVE: The goal of this study was to develop a preliminary pharmacodynamic model for dosing of the hydroxymethylglutaryl coenzyme A (HMG-CoA)-reductase inhibitors simvastatin and atorvastatin using neural network analysis. Atorvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens