Title : Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation.

Pub. Date : 2003 Sep

PMID : 12960612






1 Functional Relationships(s)
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1 We show here that two different 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins), atorvastatin and simvastatin, strongly increase the expression and functional activity of TM in human umbilical vein endothelial cells, human coronary artery endothelial cells, and EA.hy926 endothelial cells. Atorvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens