Pub. Date : 2007 Oct 1
PMID : 17622571
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 2 | Atorvastatin"s effects on MYC were specific to the inhibition of HMGcoA reductase, as treatment with mevalonate, the product of HMG-CoA reductase activity, abrogated these effects and inhibited the ability of atorvastatin to reverse or suppress tumorigenesis. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 3 | Atorvastatin"s effects on MYC were specific to the inhibition of HMGcoA reductase, as treatment with mevalonate, the product of HMG-CoA reductase activity, abrogated these effects and inhibited the ability of atorvastatin to reverse or suppress tumorigenesis. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 4 | Thus, atorvastatin, by inhibiting HMGcoA reductase, induces changes in phosphoprotein signaling that in turn prevent MYC-induced lymphomagenesis. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |