PML nuclear body scaffold ; Homo sapiens






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101 9806544 PML induces a novel caspase-independent death process. Nat Genet 1998 Nov 3
102 9834237 Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells. Blood 1998 Dec 1 5
103 9885291 SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation. J Cell Sci 1999 Feb 2
104 9891864 The molecular biology of acute promyelocytic leukemia. Cancer Treat Res 1999 2
105 10023669 Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins. Oncogene 1999 Jan 28 1
106 10023688 Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. Oncogene 1999 Jan 28 1
107 10029573 Constitutive degradation of PML/RARalpha through the proteasome pathway mediates retinoic acid resistance. Blood 1999 Mar 1 5
108 10075924 Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110. EMBO J 1999 Mar 15 1
109 10077561 Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc Natl Acad Sci U S A 1999 Mar 16 1
110 10203615 Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission. Oncol Rep 1999 May-Jun 3
111 10233384 Identification of the t(15;17) in AML FAB types other than M3: evaluation of the role of molecular screening for the PML/RARalpha rearrangement in newly diagnosed AML. The Medical Research Council (MRC) Adult Leukaemia Working Party. Br J Haematol 1999 Apr 1
112 10328107 Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. J Natl Cancer Inst 1999 May 5 2
113 10330422 CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment. J Clin Invest 1999 May 15 1
114 10356361 Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha. Mol Cell Biol Res Commun 1999 May 2
115 10359529 A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest. Oncogene 1999 May 27 2
116 10373566 PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Mol Cell Biol 1999 Jul 10
117 10374879 In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies. Leukemia 1999 May 7
118 10439807 A rapid practical RT-PCR-based approach for the detection of the PML/RAR alpha fusion transcript in acute promyelocytic leukemia. Am J Clin Pathol 1999 Aug 1
119 10504293 A dynamic connection between centromeres and ND10 proteins. J Cell Sci 1999 Oct 1
120 10539879 All trans-retinoic acid decreases early mortality in patients with promyelocytic leukemia and can be given entirely on an outpatient basis. Am J Hematol 1999 Nov 1
121 10553155 Missense mutations in the PML/RARalpha ligand binding domain in ATRA-resistant As(2)O(3) sensitive relapsed acute promyelocytic leukemia. Haematologica 1999 Nov 4
122 10556184 A modified AIDA protocol with anthracycline-based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML/RARalpha-positive acute promyelocytic leukemia. PETHEMA group. Blood 1999 Nov 1 3
123 10597230 Formation of PML/RAR alpha high molecular weight nuclear complexes through the PML coiled-coil region is essential for the PML/RAR alpha-mediated retinoic acid response. Oncogene 1999 Nov 4 5
124 10597310 The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. Oncogene 1999 Nov 25 1
125 10610177 A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet 1999 Nov 3
126 10611294 Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins. Proc Natl Acad Sci U S A 1999 Dec 21 6
127 10620019 Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies. Genes Cells 1999 Dec 3
128 10637480 The impact of differential binding of wild-type RARalpha, PML-, PLZF- and NPM-RARalpha fusion proteins towards transcriptional co-activator, RIP-140, on retinoic acid responses in acute promyelocytic leukemia. Leukemia 2000 Jan 2
129 10673742 A mutated PML/RARA found in the retinoid maturation resistant NB4 subclone, NB4-R2, blocks RARA and wild-type PML/RARA transcriptional activities. Leukemia 2000 Feb 5
130 10684855 Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J Exp Med 2000 Feb 21 2
131 10702898 Acute promyelocytic leukemia. From morphology to molecular lesions. Clin Lab Med 2000 Mar 1
132 10766166 Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia. Cancer Res 2000 Apr 1 3
133 10770516 Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. Acta Neurol Scand 2000 Apr 9
134 10784426 Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukemia (HL-60) cell line. Biol Pharm Bull 2000 Apr 2
135 10830735 Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: an useful salvage therapy. Leuk Lymphoma 2000 Jul 2
136 10865965 Treatment of relapsing acute promyelocytic leukemia by all-trans retinoic acid therapy followed by timed sequential chemotherapy and stem cell transplantation. APL Study Group. Acute promyelocytic leukemia. Leukemia 2000 Jun 1
137 10870476 Current issues in the management of acute promyelocytic leukemia. Ann Hematol 2000 May 3
138 10874212 Spicamycin and KRN5500 induce apoptosis in myeloid and lymphoid cell lines with down-regulation of bcl-2 expression and modulation of promyelocytic leukemia protein. Jpn J Cancer Res 2000 Jun 3
139 10901625 Impaired glucose tolerance (IGT) is not associated with disturbed homocysteine metabolism. Amino Acids 2000 3
140 10910048 BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity. Cancer Res 2000 Jul 1 2
141 10942370 A new morphologic classification system for acute promyelocytic leukemia distinguishes cases with underlying PLZF/RARA gene rearrangements. Blood 2000 Aug 15 1
142 10950866 PML is induced by oncogenic ras and promotes premature senescence. Genes Dev 2000 Aug 15 1
143 11007958 The promyelocytic (PML) nuclear compartment and transcription control. Biochem Pharmacol 2000 Oct 15 1
144 11050004 Altered ligand binding and transcriptional regulation by mutations in the PML/RARalpha ligand-binding domain arising in retinoic acid-resistant patients with acute promyelocytic leukemia. Blood 2000 Nov 1 3
145 11112687 Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies. J Cell Sci 2001 Jan 2
146 11133770 Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo. Blood 2001 Jan 1 4
147 11158586 Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation. Proc Natl Acad Sci U S A 2001 Jan 30 2
148 11161273 Proteasome inhibitor induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5. J Gen Virol 2001 Feb 1
149 11172537 Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies. Semin Hematol 2001 Jan 3
150 11259576 The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol 2001 Apr 1