Title : A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest.

Pub. Date : 1999 May 27

PMID : 10359529






2 Functional Relationships(s)
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1 RA-treatment induced two peaks of p21 synthesis: early (from the 2nd to the 6th hour), dependent on PML/RAR alpha expression and associated with G1-S transition and high CDK activity; late (from 3rd to the 4th day), independent from PML/RAR alpha and associated with G1 block and low CDK activity. Tretinoin PML nuclear body scaffold Homo sapiens
2 RA-treatment induced two peaks of p21 synthesis: early (from the 2nd to the 6th hour), dependent on PML/RAR alpha expression and associated with G1-S transition and high CDK activity; late (from 3rd to the 4th day), independent from PML/RAR alpha and associated with G1 block and low CDK activity. Tretinoin PML nuclear body scaffold Homo sapiens