Protein Name PML nuclear body scaffold
Organism Homo sapiens
Gene ID 5371
Gene Symbol


UniProt P29590 (PML_HUMAN)
Relationships Total Number of functionally related compound(s) : 293
Total Number of Articles : 732

PML nuclear body scaffold

Gene Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

  • protein PML
  • E3 SUMO-protein ligase PML
  • PML/RARA fusion
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