Title : A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.

Pub. Date : 1999 Nov

PMID : 10610177






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Here we show that PML, Tif1alpha and RXRalpha/RARalpha function together in a transcription complex that is dependent on retinoic acid (RA). Tretinoin PML nuclear body scaffold Homo sapiens
2 Here we show that PML, Tif1alpha and RXRalpha/RARalpha function together in a transcription complex that is dependent on retinoic acid (RA). Tretinoin PML nuclear body scaffold Homo sapiens
3 T18, similar to PML-RARalpha, disrupts the RA-dependent activity of this complex in a dominant-negative manner resulting in a growth advantage. Tretinoin PML nuclear body scaffold Homo sapiens