lysophosphatidic acid receptor 1 ; Mus musculus






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1 9717712 Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J Comp Neurol 1998 Sep 7 1
2 9721207 Complete cDNA sequence, genomic structure, and chromosomal localization of the LPA receptor gene, lpA1/vzg-1/Gpcr26. Genomics 1998 Aug 1 2
3 9931453 Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene 1999 Feb 4 3
4 10686359 Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission. Brain Res Mol Brain Res 2000 Feb 22 3
5 11549717 Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling. J Neurosci 2001 Sep 15 1
6 12069829 In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochim Biophys Acta 2002 May 23 3
7 12215548 Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol 2002 Oct 1
8 12770838 Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 2003 Sep 5
9 14697676 LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Mol Cell Neurosci 2003 Dec 1
10 15599396 Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer. J Clin Invest 2004 Dec 3
11 15684836 Lysophosphatidic acid induces clonal generation of mouse neurospheres via proliferation of Sca-1- and AC133-positive neural progenitors. Stem Cells Dev 2004 Dec 3
12 15716590 Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. J Lipid Res 2005 May 1
13 16018581 Neurochemical changes in LPA1 receptor deficient mice--a putative model of schizophrenia. Neurochem Res 2005 Mar 6
14 16171822 Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites. J Surg Res 2006 Jan 2
15 16263766 A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors. J Cell Sci 2005 Nov 15 16
16 16404130 Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors. J Pharmacol Sci 2006 Jan 5
17 16487757 Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells. Bone 2006 Jul 2
18 17056154 Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway. Neurochem Int 2007 Jan 1
19 17692995 Lysophosphatidic acid stimulates astrocyte proliferation through LPA1. Neurochem Int 2008 Jan 6
20 18003779 LPA1 receptor activation promotes renal interstitial fibrosis. J Am Soc Nephrol 2007 Dec 2
21 18066075 The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med 2008 Jan 1
22 18089565 Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptor. J Biol Chem 2008 Feb 29 9
23 18198181 Lysophosphatidic acid receptor-dependent secondary effects via astrocytes promote neuronal differentiation. J Biol Chem 2008 Mar 21 4
24 18261210 Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. Mol Pain 2008 Feb 8 4
25 18280050 Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid. Neuroscience 2008 Mar 18 5
26 18448840 Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling. Biol Reprod 2008 Aug 3
27 18703779 Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circ Res 2008 Sep 12 2
28 18708146 Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. Mol Cell Neurosci 2008 Nov 3
29 19912636 Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain. Mol Pain 2009 Nov 13 3
30 19930563 Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma. Respir Res 2009 Nov 20 2
31 20069565 LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4. J Cell Biochem 2010 Mar 1 6
32 20118541 Regulatory effect of lysophosphatidic acid on lymphocyte migration. Biol Pharm Bull 2010 1
33 20123931 Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain. J Pharmacol Exp Ther 2010 May 1
34 20230855 LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid. Prog Lipid Res 2010 Oct 2
35 20360252 Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation. Circ Res 2010 Jul 9 1
36 20649573 A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model. Br J Pharmacol 2010 Aug 2
37 20826223 Effects of lysophosphatidic acid on the in vitro proliferation and differentiation of a novel porcine preadipocyte cell line. Comp Biochem Physiol B Biochem Mol Biol 2010 Dec 2
38 21042747 Effects of lysophosphatidic acid and its receptors LPA⅓ on radiation pneumonitis. Oncol Rep 2010 Dec 2
39 21062487 Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine. Mol Pain 2010 Nov 9 1
40 21159750 Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. J Pharmacol Exp Ther 2011 Mar 5
41 21222547 Lysophosphatidic acid receptor agonists and antagonists (WO2010051053). Expert Opin Ther Pat 2011 Feb 1
42 21302283 LPA(1) -induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells. J Cell Physiol 2011 Nov 2
43 21305523 Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis Rheum 2011 May 3
44 21887497 Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors. Psychopharmacology (Berl) 2012 Mar 5
45 22015657 Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arterioscler Thromb Vasc Biol 2012 Jan 1
46 22021336 The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury. Am J Respir Cell Mol Biol 2012 Mar 1
47 22200658 Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis. Int J Oncol 2012 Apr 4
48 22348348 Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo. Cancer Sci 2012 Jun 1
49 22461625 Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain. J Biol Chem 2012 May 18 3
50 22867754 Bone defects in LPA receptor genetically modified mice. Biochim Biophys Acta 2013 Jan 1