Pub. Date : 2008 Feb 29
PMID : 18089565
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptor. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Mus musculus |
| 2 | Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptor. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Mus musculus |
| 3 | Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptor. | Phorbol Esters | lysophosphatidic acid receptor 1 | Mus musculus |
| 4 | Lysophosphatidic acid (LPA) stimulates cells by activation of five G-protein-coupled receptors, termed LPA 1-5. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Mus musculus |
| 5 | Lysophosphatidic acid (LPA) stimulates cells by activation of five G-protein-coupled receptors, termed LPA 1-5. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Mus musculus |
| 6 | Agonist-dependent internalization of LPA 1, however, requires a cluster of serine residues (amino acids 341-347) located proximal to the dileucine motif, beta-arrestin, and to a lesser extent clathrin AP-2. | Serine | lysophosphatidic acid receptor 1 | Mus musculus |
| 7 | Agonist-dependent internalization of LPA 1, however, requires a cluster of serine residues (amino acids 341-347) located proximal to the dileucine motif, beta-arrestin, and to a lesser extent clathrin AP-2. | dileucine | lysophosphatidic acid receptor 1 | Mus musculus |
| 8 | The serine cluster of LPA 1 is required for beta-arrestin2-GFP translocation to the plasma membrane and signal desensitization. | Serine | lysophosphatidic acid receptor 1 | Mus musculus |
| 9 | Evidence for the beta-arrestin independence of PMA-induced internalization of LPA 1 comes from the observations that beta-arrestin2-GFP is not recruited to the plasma membrane upon PMA treatment and that LPA 1 is readily internalized in beta-arrestin1/2 knock-out mouse embryonic fibroblasts. | Tetradecanoylphorbol Acetate | lysophosphatidic acid receptor 1 | Mus musculus |