Pub. Date : 2005 Nov 15
PMID : 16263766
16 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors. | Cholesterol | lysophosphatidic acid receptor 1 | Mus musculus |
| 2 | Lysophosphatidic acid (LPA) stimulates heterotrimeric G protein signaling by activating three closely related receptors, termed LPA(1), LPA(2) and LPA(3). | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Mus musculus |
| 3 | Lysophosphatidic acid (LPA) stimulates heterotrimeric G protein signaling by activating three closely related receptors, termed LPA(1), LPA(2) and LPA(3). | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Mus musculus |
| 4 | Here we show that in addition to promoting LPA(1) signaling, membrane cholesterol is essential for the association of LPA(1) with beta-arrestin, which leads to signal attenuation and clathrin-dependent endocytosis of LPA(1). | Cholesterol | lysophosphatidic acid receptor 1 | Mus musculus |
| 5 | Here we show that in addition to promoting LPA(1) signaling, membrane cholesterol is essential for the association of LPA(1) with beta-arrestin, which leads to signal attenuation and clathrin-dependent endocytosis of LPA(1). | Cholesterol | lysophosphatidic acid receptor 1 | Mus musculus |
| 6 | LPA(1) endocytosis was also inhibited in beta-arrestin 1 and 2-null mouse embryo fibroblasts (beta-arrestin 1/2 KO MEFs), but was restored upon re-expression of wild-type beta-arrestin 2. beta-arrestin attenuates LPA signaling as LPA(1)-dependent phosphoinositide hydrolysis was significantly elevated in beta-arrestin 1/2 KO MEFs and was reduced to wild-type levels upon re-expression of wild-type beta-arrestin. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Mus musculus |
| 7 | Interestingly, extraction of membrane cholesterol with methyl-beta-cyclodextrin inhibited LPA(1) signaling, beta-arrestin membrane recruitment and LPA(1) endocytosis. | Cholesterol | lysophosphatidic acid receptor 1 | Mus musculus |
| 8 | Interestingly, extraction of membrane cholesterol with methyl-beta-cyclodextrin inhibited LPA(1) signaling, beta-arrestin membrane recruitment and LPA(1) endocytosis. | Cholesterol | lysophosphatidic acid receptor 1 | Mus musculus |
| 9 | Interestingly, extraction of membrane cholesterol with methyl-beta-cyclodextrin inhibited LPA(1) signaling, beta-arrestin membrane recruitment and LPA(1) endocytosis. | methyl-beta-cyclodextrin | lysophosphatidic acid receptor 1 | Mus musculus |
| 10 | Interestingly, extraction of membrane cholesterol with methyl-beta-cyclodextrin inhibited LPA(1) signaling, beta-arrestin membrane recruitment and LPA(1) endocytosis. | methyl-beta-cyclodextrin | lysophosphatidic acid receptor 1 | Mus musculus |
| 11 | LPA treatment increased the detergent resistance of LPA(1) and this was inhibited by cholesterol extraction, suggesting that LPA(1) localizes to detergent-resistant membranes upon ligand stimulation. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Mus musculus |
| 12 | LPA treatment increased the detergent resistance of LPA(1) and this was inhibited by cholesterol extraction, suggesting that LPA(1) localizes to detergent-resistant membranes upon ligand stimulation. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Mus musculus |
| 13 | LPA treatment increased the detergent resistance of LPA(1) and this was inhibited by cholesterol extraction, suggesting that LPA(1) localizes to detergent-resistant membranes upon ligand stimulation. | Cholesterol | lysophosphatidic acid receptor 1 | Mus musculus |
| 14 | LPA treatment increased the detergent resistance of LPA(1) and this was inhibited by cholesterol extraction, suggesting that LPA(1) localizes to detergent-resistant membranes upon ligand stimulation. | Cholesterol | lysophosphatidic acid receptor 1 | Mus musculus |
| 15 | These data indicate that although LPA(1) is internalized by clathrin- and beta-arrestin dependent endocytosis, membrane cholesterol is critical for LPA(1) signaling, membrane recruitment of beta-arrestins and LPA(1) endocytosis. | Cholesterol | lysophosphatidic acid receptor 1 | Mus musculus |
| 16 | These data indicate that although LPA(1) is internalized by clathrin- and beta-arrestin dependent endocytosis, membrane cholesterol is critical for LPA(1) signaling, membrane recruitment of beta-arrestins and LPA(1) endocytosis. | Cholesterol | lysophosphatidic acid receptor 1 | Mus musculus |