Title : LPA1 receptor activation promotes renal interstitial fibrosis.

Pub. Date : 2007 Dec

PMID : 18003779






2 Functional Relationships(s)
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1 Furthermore, treatment of wild-type mice with the LPA1 antagonist Ki16425 similarly reduced fibrosis and significantly attenuated renal expression of the profibrotic cytokines connective tissue growth factor (CTGF) and transforming growth factor beta (TGFbeta). 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid lysophosphatidic acid receptor 1 Mus musculus
2 In conclusion, LPA, likely acting through LPA1, is involved in obstruction-induced TIF. lysophosphatidic acid lysophosphatidic acid receptor 1 Mus musculus