Title : The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.

Pub. Date : 2008 Jan

PMID : 18066075






1 Functional Relationships(s)
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1 We show that lysophosphatidic acid levels increase in bronchoalveolar lavage fluid following lung injury in the bleomycin model of pulmonary fibrosis, and that mice lacking one of its receptors, LPA1, are markedly protected from fibrosis and mortality in this model. lysophosphatidic acid lysophosphatidic acid receptor 1 Mus musculus