signal transducer and activator of transcription 5A ; Homo sapiens






960 Article(s)
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901 34077739 Osimertinib-resistant NSCLC cells activate ERBB2 and YAP/TAZ and are killed by neratinib. Biochem Pharmacol 2021 Aug 1
902 34089720 Jak-STAT Inhibition Mediates Romidepsin and Mechlorethamine Synergism in Cutaneous T-Cell Lymphoma. J Invest Dermatol 2021 Dec 2
903 34097573 Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function. Platelets 2022 Apr 3 1
904 34099621 The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML. Blood Cancer J 2021 Jun 7 2
905 34099760 Human immune system adaptations to simulated microgravity revealed by single-cell mass cytometry. Sci Rep 2021 Jun 7 2
906 34117374 Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation. Cancer Gene Ther 2021 Jun 11 1
907 34121564 Novel CD123 polyaptamer hydrogel edited by Cas9/sgRNA for AML-targeted therapy. Drug Deliv 2021 Dec 1
908 34188118 Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer. Sci Rep 2021 Jun 29 9
909 34209829 Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells. Cells 2021 Jun 29 2
910 34262659 Combined inhibition of STAT and Notch signalling effectively suppresses tumourigenesis by inducing apoptosis and inhibiting proliferation, migration and invasion in glioblastoma cells. Anim Cells Syst (Seoul) 2021 1
911 34288360 Whole-genome analysis of TET dioxygenase function in regulatory T cells. EMBO Rep 2021 Aug 4 2
912 34318593 Anti-growth and pro-apoptotic effects of dasatinib on human oral cancer cells through multi-targeted mechanisms. J Cell Mol Med 2021 Sep 2
913 34324169 Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation. Target Oncol 2021 Sep 1
914 34336684 STAT5a Confers Doxorubicin Resistance to Breast Cancer by Regulating ABCB1. Front Oncol 2021 4
915 34360855 Rationale for a Combination Therapy with the STAT5 Inhibitor AC-4-130 and the MCL1 Inhibitor S63845 in the Treatment of FLT3-Mutated or TET2-Mutated Acute Myeloid Leukemia. Int J Mol Sci 2021 Jul 28 2
916 34360911 Pyrimethamine Modulates Interplay between Apoptosis and Autophagy in Chronic Myelogenous Leukemia Cells. Int J Mol Sci 2021 Jul 29 2
917 34367046 Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation. Front Neurol 2021 1
918 34372612 Targeting JAK/STAT Signaling Antagonizes Resistance to Oncolytic Reovirus Therapy Driven by Prior Infection with HTLV-1 in Models of T-Cell Lymphoma. Viruses 2021 Jul 20 1
919 34396051 AXL Inhibition Represents a Novel Therapeutic Approach in <i>BCR-ABL</i> Negative Myeloproliferative Neoplasms. Hemasphere 2021 Sep 2
920 34408231 Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy. Sci Rep 2021 Aug 18 1
921 34415853 Improved green thermal activated delayed fluorescence OLEDs based on thermally evaporated distributed Bragg reflector (DBR) of MgF<sub>2</sub>/ZnS. Nanotechnology 2021 Aug 20 1
922 34443392 Lignans from <i>Machilus thunbergii</i> as Thymic Stromal Lymphopoietin Inhibitors. Molecules 2021 Aug 8 2
923 34462525 TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways. Leukemia 2022 Feb 1
924 34506850 Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells. J Allergy Clin Immunol 2022 Apr 1
925 34536521 Integrative analysis of potential biomarkers and immune cell infiltration in Parkinson's disease. Brain Res Bull 2021 Dec 1
926 34545658 MK-6, a novel not-α IL-2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance. Cancer Sci 2021 Nov 1
927 34630419 Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis <i>In Vivo</i> and Baseline Signaling Profile Associates With Treatment Response. Front Immunol 2021 1
928 34635505 GATM-Mediated Creatine Biosynthesis Enables Maintenance of FLT3-ITD-Mutant Acute Myeloid Leukemia. Mol Cancer Res 2022 Feb 2
929 34638347 Carfilzomib Enhances the Suppressive Effect of Ruxolitinib in Myelofibrosis. Cancers (Basel) 2021 Sep 28 1
930 34650929 Histone Deacetylase Inhibitor Trichostatin A Reduces Endothelial Cell Proliferation by Suppressing STAT5A-Related Gene Transcription. Front Oncol 2021 1
931 34665220 Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity. J Exp Med 2021 Dec 6 1
932 34665271 Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. Arch Toxicol 2022 Jan 1
933 34668282 Tailoring Co3d and O2p Band Centers to Inhibit Oxygen Escape for Stable 4.6 V LiCoO<sub>2</sub> Cathodes. Angew Chem Int Ed Engl 2021 Dec 20 2
934 34673425 JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia. Biomed Pharmacother 2021 Dec 1
935 34715067 Pharmacologic control of homeostatic and antigen-driven proliferation to target HIV-1 persistence. Biochem Pharmacol 2021 Dec 1
936 34716187 CSF2-STAT5 Signaling in TAMs Contributes to CSF1R Inhibition Resistance. Cancer Discov 2022 Jan 2
937 34719574 [Pharmacological characteristics and clinical study results of Pemigatinib (Pemazyre<sup>®</sup> Tablets), a selective fibroblast growth factor receptor (FGFR) inhibitor]. Nihon Yakurigaku Zasshi 2021 1
938 34745769 Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner. Oncoimmunology 2021 1
939 34749590 Mutated JAK2 signal transduction in human Induced Pluripotent Stem Cell (iPSC)-derived Megakaryocytes. Platelets 2021 Nov 9 1
940 34761621 FAT10 stimulates the development of osteosarcoma by regulating the JAK/STAT signaling pathway. J BUON 2021 Sep-Oct 1
941 34827970 Beta-Sitosterol Promotes Milk Protein and Fat Syntheses-Related Genes in Bovine Mammary Epithelial Cells. Animals (Basel) 2021 Nov 12 2
942 34842047 STAT5 inhibitor Pimozide as a probable therapeutic option in overcoming Ponatinib resistance in K562 leukemic cells. J Biomol Struct Dyn 2021 Nov 28 7
943 34858500 Key Markers Involved in the Anticolon Cancer Response of CD8+ T Cells through the Regulation of Cholesterol Metabolism. J Oncol 2021 1
944 34866251 22-kD growth hormone-induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation. Biofactors 2022 Jan 2
945 34905258 Asymmetrically Substituted m-Terphenyl Phosphates Inhibit the Transcription Factor STAT5a. Chembiochem 2022 Feb 16 6
946 34948112 The Framework for Human Host Immune Responses to Four Types of Parasitic Infections and Relevant Key JAK/STAT Signaling. Int J Mol Sci 2021 Dec 10 2
947 34959180 Degrading FLT3-ITD protein by proteolysis targeting chimera (PROTAC). Bioorg Chem 2022 Feb 1
948 35136485 GZ17-6.02 and axitinib interact to kill renal carcinoma cells. Oncotarget 2022 2
949 35167281 Thermodynamic and Kinetic Studies on the Conversion of Solvent-Shared to Contact Ion Pairs in Sparingly Soluble MF<sub>2</sub> (M = Mg<sup>2+</sup> and Ca<sup>2+</sup>) Aqueous Solutions: Implications for Understanding Supersaturated Behavior and Association Constant Determination. J Phys Chem B 2022 Feb 24 2
950 35204716 Exogenous Lactogenic Signaling Stimulates Beta Cell Replication In Vivo and In Vitro. Biomolecules 2022 Jan 26 1