Protein Name signal transducer and activator of transcription 5A
Organism Homo sapiens
Gene ID 6776
Gene Symbol


UniProt P42229 (STA5A_HUMAN), A0A384N5W4 (A0A384N5W4_HUMAN), K7EK35 (K7EK35_HUMAN), A0A7I2YQF1 (A0A7I2YQF1_HUMAN), A8K6I5 (A8K6I5_HUMAN), Q59GY7 (Q59GY7_HUMAN)
Relationships Total Number of functionally related compound(s) : 575
Total Number of Articles : 960

signal transducer and activator of transcription 5A

Gene Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

  • signal transducer and activator of transcription 5A
  • epididymis secretory sperm binding protein
  • MGF
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