Pub. Date : 2021
PMID : 34336684
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we identified STAT5a as a chemoresistance inducer that regulates the expression of ABCB1 in breast cancer and can be targeted by pimozide, an FDA-approved psychotropic drug. | Pimozide | signal transducer and activator of transcription 5A | Homo sapiens |
| 2 | First, we found that STAT5a and ABCB1 were expressed at higher levels in doxorubicin-resistant cell lines and chemoresistant patients, and their expression was positively correlated. | Doxorubicin | signal transducer and activator of transcription 5A | Homo sapiens |
| 3 | Subsequently, the efficacy of pimozide in inhibiting STAT5a and sensitizing doxorubicin-resistant breast cancer cells was tested. | Pimozide | signal transducer and activator of transcription 5A | Homo sapiens |
| 4 | Targeting STAT5a might be a promising strategy for treating doxorubicin-resistant breast cancer. | Doxorubicin | signal transducer and activator of transcription 5A | Homo sapiens |