Title : GATM-Mediated Creatine Biosynthesis Enables Maintenance of FLT3-ITD-Mutant Acute Myeloid Leukemia.

Pub. Date : 2022 Feb

PMID : 34635505






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Our data show that FLT3-ITD constitutively activates the STAT5 signaling pathway, which upregulates the expression of glycine amidinotransferase (GATM), the first rate-limiting enzyme of de novo creatine biosynthesis. Glycine signal transducer and activator of transcription 5A Homo sapiens
2 Our data show that FLT3-ITD constitutively activates the STAT5 signaling pathway, which upregulates the expression of glycine amidinotransferase (GATM), the first rate-limiting enzyme of de novo creatine biosynthesis. Creatine signal transducer and activator of transcription 5A Homo sapiens