sodium voltage-gated channel alpha subunit 9 ; Homo sapiens






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1 9975052 Projectile and target autoionization electron emission in 700-eV Ne+-Na/M (M=Cr, Cu, Mo, and Pt) collisions. Phys Rev B Condens Matter 1994 Oct 1 2
2 12270053 Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3. Eur J Neurosci 2002 Aug 1
3 15385606 Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy. J Neurosci 2004 Sep 22 1
4 15955112 SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels. J Invest Dermatol 2005 Jun 2
5 15958509 Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons. Brain 2005 Aug 1
6 16301337 Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats. Mol Pharmacol 2006 Mar 1
7 16702558 A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proc Natl Acad Sci U S A 2006 May 23 1
8 16895935 Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria. J Antimicrob Chemother 2006 Oct 4
9 17294067 Characterization of a familial case with primary erythromelalgia from Taiwan. J Neurol 2007 Feb 1
10 17430993 A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. J Physiol 2007 Jun 15 12
11 17470132 Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin Genet 2007 Apr 4
12 18027973 Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7. Biochemistry 2007 Dec 18 4
13 18079277 State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine. Mol Pharmacol 2008 Mar 4
14 18249135 Identification and characterization of the promoter region of the Nav1.7 voltage-gated sodium channel gene (SCN9A). Mol Cell Neurosci 2008 Mar 2
15 18426592 Nav1.7 expression is increased in painful human dental pulp. Mol Pain 2008 Apr 21 1
16 18485418 Effect of dexamethasone on voltage-gated Na+ channel in cultured human bronchial smooth muscle cells. Life Sci 2008 Jun 6 6
17 18728100 ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol 2008 Nov 1
18 18806059 Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. Anesth Analg 2008 Oct 1
19 18978189 Function and role of voltage-gated sodium channel NaV1.7 expressed in aortic smooth muscle cells. Am J Physiol Heart Circ Physiol 2009 Jan 2
20 19217209 Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine. Pain 2009 Apr 2
21 19304393 Two novel SCN9A mutations causing insensitivity to pain. Pain 2009 May 2
22 19549232 Treatment with carbamazepine and gabapentin of a patient with primary erythermalgia (erythromelalgia) identified to have a mutation in the SCN9A gene, encoding a voltage-gated sodium channel. Clin Exp Dermatol 2009 Dec 4
23 19557861 A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia. Ann Neurol 2009 Jun 1
24 19773645 Ranolazine attenuates behavioral signs of neuropathic pain. Behav Pharmacol 2009 Dec 1
25 19835862 Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer. Eur J Pharmacol 2009 Dec 25 1
26 20038812 Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents. J Clin Invest 2010 Jan 4
27 20529343 Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability. Mol Pain 2010 Jun 8 6
28 20580661 Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models. Neuroscience 2010 Aug 25 1
29 20693878 Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology 2010 Sep 3
30 20947311 Antiviral activity of 5'-O-carbonate-2',3'-dideoxy-3'-thiacytidine prodrugs against hepatitis B virus in HepG2 2.2.15 cells. Int J Antimicrob Agents 2010 Dec 1
31 20959280 Long-term remission of primary erythermalgia with R1150W polymorphism in SCN9A after chemical lumbar sympathectomy. Eur J Dermatol 2010 Nov-Dec 2
32 21115638 Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents. J Physiol 2011 Feb 1 2
33 21570288 Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain. Bioorg Med Chem Lett 2011 Jun 15 2
34 21634377 Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J Med Chem 2011 Jul 14 5
35 21715690 Voltage-gated sodium channel Nav1.7 maintains the membrane potential and regulates the activation and chemokine-induced migration of a monocyte-derived dendritic cell subset. J Immunol 2011 Aug 1 2
36 21788423 Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide. Mol Pharmacol 2011 Oct 4
37 21882461 Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes 2010 2
38 21939494 Two novel SCN9A gene heterozygous mutations may cause partial deletion of pain perception. Pain Med 2011 Oct 1
39 22098589 Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors. J Med Chem 2012 Jan 12 1
40 22473870 Contribution of genetic variants to pain susceptibility in Parkinson disease. Eur J Pain 2012 Oct 1
41 22522923 Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: a possible basis for modulation of excitability in vivo. Channels (Austin) 2012 Jan-Feb 2
42 22605564 Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide--protoxin II. J Pept Sci 2012 Jul 1
43 23077250 Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]. Proc Natl Acad Sci U S A 2012 Oct 30 2
44 23376079 A new Nav1.7 mutation in an erythromelalgia patient. Biochem Biophys Res Commun 2013 Mar 1 2
45 23382806 Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line. PLoS One 2013 5
46 23434582 Endothelin-1-induced down-regulation of NaV1.7 expression in adrenal chromaffin cells: attenuation of catecholamine secretion and tau dephosphorylation. FEBS Lett 2013 Apr 2 6
47 23450472 [Association between mutations of SCN9A gene and pain related to Parkinsonism]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2013 Feb 1
48 23523779 Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena. Peptides 2013 Jun 9
49 23527544 Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1. ACS Chem Biol 2013 4
50 23531742 Voltage-gated sodium channels: pharmaceutical targets via anticonvulsants to treat epileptic syndromes. Channels (Austin) 2013 May-Jun 1