Title : Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Pub. Date : 2011 Jul 14

PMID : 21634377






5 Functional Relationships(s)
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1 Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Tetrodotoxin sodium voltage-gated channel alpha subunit 9 Homo sapiens
2 Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Tetrodotoxin sodium voltage-gated channel alpha subunit 9 Homo sapiens
3 Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Tetrodotoxin sodium voltage-gated channel alpha subunit 9 Homo sapiens
4 Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Tetrodotoxin sodium voltage-gated channel alpha subunit 9 Homo sapiens
5 Herein, we report structure-activity relationships for a novel series of 2,4-diaminotriazines that inhibit hNav1.7. 2,4-diaminotriazine sodium voltage-gated channel alpha subunit 9 Homo sapiens