mitogen-activated protein kinase kinase kinase 5 ; Homo sapiens






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401 31814016 Dienogest regulates apoptosis, proliferation, and invasiveness of endometriotic cyst stromal cells via endoplasmic reticulum stress induction. Mol Hum Reprod 2020 Jan 1 1
402 31912702 Long noncoding RNA-regulator of reprogramming alleviates hypoxia-induced cerebral injury in mice model and human via modulating apoptosis complexes. J Integr Neurosci 2019 Dec 30 4
403 31922706 Moderate hyperoxia plays a protective role in lung bronchial epithelial cells. Clin Invest Med 2019 Dec 29 1
404 31926625 Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway. Redox Biol 2020 Jan 5
405 31952288 Endoplasmic Reticulum Stress Contributes to Indomethacin-Induced Glioma Apoptosis. Int J Mol Sci 2020 Jan 15 3
406 32006563 H<sub>2</sub>S attenuates injury after ischemic stroke by diminishing the assembly of CaMKII with ASK1-MKK3-p38 signaling module. Behav Brain Res 2020 Apr 20 3
407 32124968 Histone deacetylase inhibitor OBP‑801 and amrubicin synergistically inhibit the growth of squamous cell lung carcinoma by inducing mitochondrial ASK1‑dependent apoptosis. Int J Oncol 2020 Mar 12
408 32147362 Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials. J Hepatol 2020 Jul 1
409 32289582 Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). Eur J Med Chem 2020 Jun 1 5
410 32452100 Tumour-associated macrophages as a novel target of VEGI-251 in cancer therapy. J Cell Mol Med 2020 Jul 2
411 32544093 Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms. JCI Insight 2020 Jul 23 8
412 32640963 Periplogenin Activates ROS-ER Stress Pathway to Trigger Apoptosis via BIP-eIF2α- CHOP and IRE1α-ASK1-JNK Signaling Routes. Anticancer Agents Med Chem 2021 5
413 32717251 Involvement of endoplasmic reticulum stress response and IRE1-mediated ASK1/JNK/Mcl-1 pathways in silver nanoparticle-induced apoptosis of human retinal pigment epithelial cells. Toxicology 2020 Sep 2
414 32841541 Phase II trial of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma after disease progression on sorafenib. Cancer Med 2020 Oct 2
415 32876895 MicroRNA-532-3p Regulates Pro-Inflammatory Human THP-1 Macrophages by Targeting ASK1/p38 MAPK Pathway. Inflammation 2021 Feb 1
416 32982289 Theabrownin Induces Apoptosis and Tumor Inhibition of Hepatocellular Carcinoma Huh7 Cells Through ASK1-JNK-c-Jun Pathway. Onco Targets Ther 2020 1
417 32984087 Regulation of Cellular Stress Signaling in Bladder Ischemia. Res Rep Urol 2020 1
418 32996404 <i>In silico</i> and <i>in vitro</i> investigations on the protein-protein interactions of glutathione S-transferases with mitogen-activated protein kinase 8 and apoptosis signal-regulating kinase 1. J Biomol Struct Dyn 2022 Feb 1
419 33039870 Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca<sup>2+</sup>-ASK1-JNK pathway in human granulosa cell line KGN. Ecotoxicol Environ Saf 2021 Jan 15 5
420 33108364 β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes. PLoS One 2020 2
421 33189448 Bisphenol AF induces apoptosis via estrogen receptor beta (ERβ) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN. Environ Pollut 2021 Feb 1 3
422 33251987 Role of cardiac drugs and flavonoids on the IRE1-JNK pathway as revealed by re-ranked molecular docking scores, MM/PBSA and umbrella sampling. J Biomol Struct Dyn 2022 May 3
423 33348022 Endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity may be therapeutically targeted by natural and chemical compounds: A review. Pharmacol Res 2021 Feb 1
424 33360793 Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem 2021 Feb 5 1
425 33524379 RIPK1 inhibitor ameliorates the MPP<sup>+</sup>/MPTP-induced Parkinson's disease through the ASK1/JNK signalling pathway. Brain Res 2021 Apr 15 1
426 33631173 Apoptosis signal-regulating kinase 1 inhibition reverses deleterious indoxyl sulfate-mediated endothelial effects. Life Sci 2021 May 1 5
427 33667419 Computational model of cardiomyocyte apoptosis identifies mechanisms of tyrosine kinase inhibitor-induced cardiotoxicity. J Mol Cell Cardiol 2021 Jun 1
428 33692842 Wogonoside promotes apoptosis and ER stress in human gastric cancer cells by regulating the IRE1α pathway. Exp Ther Med 2021 Apr 2
429 33781891 Epigenetic silencing of GCH1promotes hepatocellular carcinoma growth by activating superoxide anion-mediated ASK1/p38 signaling via inhibiting tetrahydrobiopterin de novo biosynthesis. Free Radic Biol Med 2021 May 20 6
430 33857660 Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge. Transl Res 2021 Sep 1
431 33906048 Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors. Eur J Med Chem 2021 Aug 5 2
432 33907844 Vanillin downregulates NNMT and attenuates NNMT‑related resistance to 5‑fluorouracil via ROS‑induced cell apoptosis in colorectal cancer cells. Oncol Rep 2021 Jun 2
433 33920356 Endoplasmic Reticulum Stress Contributes to Gefitinib-Induced Apoptosis in Glioma. Int J Mol Sci 2021 Apr 11 1
434 33990641 trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway. Sci Rep 2021 May 14 8
435 34020281 Cadmium induces apoptosis of human granulosa cell line KGN via mitochondrial dysfunction-mediated pathways. Ecotoxicol Environ Saf 2021 Sep 1 1
436 34070036 Epigenetic Insights and Potential Modifiers as Therapeutic Targets in <i>β</i>-Thalassemia. Biomolecules 2021 May 18 1
437 34133989 Activation of type 4 metabotropic glutamate receptor attenuates oxygen and glucose deprivation-induced apoptosis in human neural stem cells via inhibition of ASK1-p38 signaling pathway. Brain Res 2021 Sep 15 1
438 34144391 Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules. Redox Biol 2021 Sep 2
439 34158609 Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells. Exp Mol Med 2021 Jun 2
440 34209102 Prdx1 Interacts with ASK1 upon Exposure to H<sub>2</sub>O<sub>2</sub> and Independently of a Scaffolding Protein. Antioxidants (Basel) 2021 Jun 30 2
441 34348125 Apocynin attenuates diabetic cardiomyopathy by suppressing ASK1-p38/JNK signaling. Eur J Pharmacol 2021 Oct 15 1
442 34389432 A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis. Cancer Lett 2021 Nov 1 3
443 34427546 Ketamine enhances autophagy and endoplasmic reticulum stress in rats and SV-HUC-1 cells via activating IRE1-TRAF2-ASK1-JNK pathway. Cell Cycle 2021 Sep 1
444 34440075 Au<sub>2</sub>phen and Auoxo6, Two Dinuclear Oxo-Bridged Gold(III) Compounds, Induce Apoptotic Signaling in Human Ovarian A2780 Cancer Cells. Biomedicines 2021 Jul 23 2
445 34498942 PDK4 Decrease Neuronal Apoptosis <i>via</i> Inhibiting ROS-ASK1/P38 Pathway in Early Brain Injury After Subarachnoid Hemorrhage. Antioxid Redox Signal 2022 Mar 2
446 34560123 Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during As<sub>2</sub>O<sub>3</sub>-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology 2021 Oct 2
447 34732784 Thioredoxin-1 mediates neuroprotection of Schisanhenol against MPP<sup>+</sup>-induced apoptosis via suppression of ASK1-P38-NF-κB pathway in SH-SY5Y cells. Sci Rep 2021 Nov 3 2
448 34850538 Surfactin induces ER stress-mediated apoptosis via IRE1-ASK1-JNK signaling in human osteosarcoma. Environ Toxicol 2022 Mar 3
449 34895315 Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER-mitochondria crosstalk in SiHa cells. Parasit Vectors 2021 Dec 11 1
450 34948191 Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions. Int J Mol Sci 2021 Dec 13 2