Pub. Date : 2021 Feb 1
PMID : 33189448
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bisphenol AF induces apoptosis via estrogen receptor beta (ERbeta) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN. | bis(4-hydroxyphenyl)sulfone | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | After blocking the corresponding pathway, it was found that ROS mediates ASK1 and JNK activation. | ros | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | These results suggest that BPAF has potential reproductive toxicity for females, and ROS-ASK1-JNK axis may play a key role in BPAF-induced ovarian dysfunction. | 4,4'-hexafluorisopropylidene diphenol | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |