Pub. Date : 2020 Mar
PMID : 32124968
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histone deacetylase inhibitor OBP-801 and amrubicin synergistically inhibit the growth of squamous cell lung carcinoma by inducing mitochondrial ASK1-dependent apoptosis. | YM753 compound | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | Histone deacetylase inhibitor OBP-801 and amrubicin synergistically inhibit the growth of squamous cell lung carcinoma by inducing mitochondrial ASK1-dependent apoptosis. | amrubicin | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | The results demonstrated that a combined treatment with the potent histone deacetylase (HDAC) inhibitor OBP-801 and the third-generation anthracycline amrubicin synergistically inhibited the viability of SQCLC cell lines by inducing apoptosis signal-regulating kinase 1 (ASK1)-dependent, as well as JNK- and p38 mitogen-activated protein kinase (MAPK)-independent apoptosis. | YM753 compound | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | The results demonstrated that a combined treatment with the potent histone deacetylase (HDAC) inhibitor OBP-801 and the third-generation anthracycline amrubicin synergistically inhibited the viability of SQCLC cell lines by inducing apoptosis signal-regulating kinase 1 (ASK1)-dependent, as well as JNK- and p38 mitogen-activated protein kinase (MAPK)-independent apoptosis. | YM753 compound | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | The results demonstrated that a combined treatment with the potent histone deacetylase (HDAC) inhibitor OBP-801 and the third-generation anthracycline amrubicin synergistically inhibited the viability of SQCLC cell lines by inducing apoptosis signal-regulating kinase 1 (ASK1)-dependent, as well as JNK- and p38 mitogen-activated protein kinase (MAPK)-independent apoptosis. | Anthracyclines | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 6 | The results demonstrated that a combined treatment with the potent histone deacetylase (HDAC) inhibitor OBP-801 and the third-generation anthracycline amrubicin synergistically inhibited the viability of SQCLC cell lines by inducing apoptosis signal-regulating kinase 1 (ASK1)-dependent, as well as JNK- and p38 mitogen-activated protein kinase (MAPK)-independent apoptosis. | Anthracyclines | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 7 | The results demonstrated that a combined treatment with the potent histone deacetylase (HDAC) inhibitor OBP-801 and the third-generation anthracycline amrubicin synergistically inhibited the viability of SQCLC cell lines by inducing apoptosis signal-regulating kinase 1 (ASK1)-dependent, as well as JNK- and p38 mitogen-activated protein kinase (MAPK)-independent apoptosis. | amrubicin | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 8 | The results demonstrated that a combined treatment with the potent histone deacetylase (HDAC) inhibitor OBP-801 and the third-generation anthracycline amrubicin synergistically inhibited the viability of SQCLC cell lines by inducing apoptosis signal-regulating kinase 1 (ASK1)-dependent, as well as JNK- and p38 mitogen-activated protein kinase (MAPK)-independent apoptosis. | amrubicin | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 9 | OBP-801 treatment strongly induced the protein expression levels of thioredoxin-interacting protein (TXNIP), and amrubicin treatment increased the levels of intracellular reactive oxygen species (ROS), which suggested that this combination oxidized and dissociated thioredoxin 2 (Trx2) from mitochondrial ASK1 and activated ASK1. | YM753 compound | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 10 | OBP-801 treatment strongly induced the protein expression levels of thioredoxin-interacting protein (TXNIP), and amrubicin treatment increased the levels of intracellular reactive oxygen species (ROS), which suggested that this combination oxidized and dissociated thioredoxin 2 (Trx2) from mitochondrial ASK1 and activated ASK1. | YM753 compound | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 11 | OBP-801 treatment strongly induced the protein expression levels of thioredoxin-interacting protein (TXNIP), and amrubicin treatment increased the levels of intracellular reactive oxygen species (ROS), which suggested that this combination oxidized and dissociated thioredoxin 2 (Trx2) from mitochondrial ASK1 and activated ASK1. | amrubicin | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 12 | OBP-801 treatment strongly induced the protein expression levels of thioredoxin-interacting protein (TXNIP), and amrubicin treatment increased the levels of intracellular reactive oxygen species (ROS), which suggested that this combination oxidized and dissociated thioredoxin 2 (Trx2) from mitochondrial ASK1 and activated ASK1. | amrubicin | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |