Title : Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARĪ³ binodal complementary modules.

Pub. Date : 2021 Sep

PMID : 34144391






2 Functional Relationships(s)
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1 Bortezomib-induced proteasomal inhibition caused severe hepatocellular injury independent of ER stress via proapoptotic Apoptosis Signal-regulating Kinase 1 (ASK1)- c-Jun N-terminal kinase (JNK1)- p38 signaling concomitant with inadequate peroxisome proliferator-activated receptor gamma (PPARgamma)- Nuclear factor erythroid 2-related factor 2 (Nrf2) -driven antioxidant response. Bortezomib mitogen-activated protein kinase kinase kinase 5 Homo sapiens
2 Bortezomib-induced proteasomal inhibition caused severe hepatocellular injury independent of ER stress via proapoptotic Apoptosis Signal-regulating Kinase 1 (ASK1)- c-Jun N-terminal kinase (JNK1)- p38 signaling concomitant with inadequate peroxisome proliferator-activated receptor gamma (PPARgamma)- Nuclear factor erythroid 2-related factor 2 (Nrf2) -driven antioxidant response. Bortezomib mitogen-activated protein kinase kinase kinase 5 Homo sapiens