Title : Wogonoside promotes apoptosis and ER stress in human gastric cancer cells by regulating the IRE1α pathway.

Pub. Date : 2021 Apr

PMID : 33692842






2 Functional Relationships(s)
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1 In addition, small interfering RNA-mediated silencing of IRE1alpha suppressed the activity of the IRE1alpha-TRAF2-ASK1 complex and prevented wogonoside-induced cell apoptosis. wogonoside mitogen-activated protein kinase kinase kinase 5 Homo sapiens
2 In conclusion, the results of the present study suggested that wogonoside exhibited antitumor activity by inducing ER stress-associated cell death through the IRE1alpha-TRAF2-ASK1 pathway. wogonoside mitogen-activated protein kinase kinase kinase 5 Homo sapiens