2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid






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101 30318121 miR-93-5p suppresses cellular senescence by directly targeting Bcl-w and p21. Biochem Biophys Res Commun 2018 Nov 10 1
102 30370550 Effects of IGFBP3 gene silencing mediated inhibition of ERK/MAPK signaling pathway on proliferation, apoptosis, autophagy, and cell senescence in rats nucleus pulposus cells. J Cell Physiol 2019 Jun 1
103 30476917 Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence. Cell Physiol Biochem 2018 2
104 30668541 Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts <i>in vitro</i>. Aging (Albany NY) 2019 Jan 21 1
105 30743996 HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells. Cancers (Basel) 2019 Feb 8 1
106 30789795 LncRNA-ANRIL inhibits cell senescence of vascular smooth muscle cells by regulating miR-181a/Sirt1. Biochem Cell Biol 2019 Oct 1
107 31074217 Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway. Korean Circ J 2019 Jul 2
108 31220953 Salicin prevents TNF-α-induced cellular senescence in human umbilical vein endothelial cells (HUVECs). Artif Cells Nanomed Biotechnol 2019 Dec 1
109 31284268 Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury. Aging (Albany NY) 2019 Jul 8 3
110 31305507 SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs. J Vis Exp 2019 Jun 28 1
111 31359662 [Ginsenoside Rg_1 induces leukemia stem cell senescence via SIRT1/TSC_2 signal axis]. Zhongguo Zhong Yao Za Zhi 2019 Jun 2
112 31689464 Human CCR6+ Th17 Lymphocytes Are Highly Sensitive to Radiation-Induced Senescence and Are a Potential Target for Prevention of Radiation-Induced Toxicity. Int J Radiat Oncol Biol Phys 2020 Sep 1 1
113 31730896 Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis. Cell Signal 2020 Feb 2
114 32092035 Pivotal role of NF-κB in cellular senescence of experimental pituitary tumours. J Endocrinol 2020 May 1
115 32103583 Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration. J Cachexia Sarcopenia Muscle 2020 Aug 1
116 32104405 3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing. Asian J Pharm Sci 2018 Jul 1
117 32162364 IRX5 prompts genomic instability in colorectal cancer cells. J Cell Biochem 2020 Nov 1
118 32216239 [Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI]. Zhonghua Nan Ke Xue 2019 Mar 1
119 32233024 Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity. Aging Cell 2020 Apr 1
120 32235006 Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway. Aging (Albany NY) 2020 Apr 1 1
121 32317087 Protein kinase CK2 activates Nrf2 via autophagic degradation of Keap1 and activation of AMPK in human cancer cells. BMB Rep 2020 May 1
122 33111210 6,4'-dihydroxy-7-methoxyflavanone protects against H<sub>2</sub>O<sub>2</sub>-induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation. Mol Cell Biochem 2021 Feb 3
123 33125520 Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity. Diabetologia 2021 Jan 1
124 33144900 OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes. Pain Res Manag 2020 1
125 33314719 Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells. Orthop Surg 2021 Apr 1
126 33390051 Renovascular Disease Induces Senescence in Renal Scattered Tubular-Like Cells and Impairs Their Reparative Potency. Hypertension 2021 Feb 1
127 33392891 MiR-217 promotes endothelial cell senescence through the SIRT1/p53 signaling pathway. J Mol Histol 2021 Apr 3
128 33393185 IL-6/STAT3-mediated autophagy participates in the development of age-related glomerulosclerosis. J Biochem Mol Toxicol 2021 Apr 1
129 33414460 Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Cell Death Dis 2021 Jan 4 2
130 33448323 Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1. Int J Mol Med 2021 Mar 1
131 33452687 TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells. J Cell Physiol 2021 Jul 1
132 33658395 Ablation of CRBN induces loss of type I collagen and SCH in mouse skin by fibroblast senescence via the p38 MAPK pathway. Aging (Albany NY) 2021 Mar 3 2
133 33782392 Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells. Cell Death Dis 2021 Mar 29 1
134 34339841 Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21<sup>cip1</sup> expression. Biochim Biophys Acta Mol Basis Dis 2021 Nov 1 1
135 34382399 Omarigliptin Prevents TNF-α-Induced Cellular Senescence in Rat Aorta Vascular Smooth Muscle Cells. Chem Res Toxicol 2021 Sep 20 2
136 34434486 Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain. Oxid Med Cell Longev 2021 2
137 34495872 HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells. Aging (Albany NY) 2021 Sep 8 1
138 34943054 Peroxiredoxin 6 Applied after Exposure Attenuates Damaging Effects of X-ray Radiation in 3T3 Mouse Fibroblasts. Antioxidants (Basel) 2021 Dec 5 1
139 35001806 Safinamide protects against amyloid β (Aβ)-induced oxidative stress and cellular senescence in M17 neuronal cells. Bioengineered 2022 Jan 2
140 35121394 Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27. Phytomedicine 2022 Jan 10 1
141 35221295 [Integrin α3β1 signaling in regulation of the SK-Mel-147 melanoma cell senescence]. Biomed Khim 2022 Jan 2
142 35325405 Minimal Cube Explant Provides Optimal Isolation Condition of Mesenchymal Stem Cells from Umbilical Cord. Tissue Eng Regen Med 2022 Mar 24 1
143 35378512 Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts. Aging (Albany NY) 2022 Apr 4 3
144 35388306 Rg1 Protects Hematopoietic Stem Cells from LiCl-Induced Oxidative Stress via Wnt Signaling Pathway. Evid Based Complement Alternat Med 2022 1
145 35397747 Inhibition of Clusterin Represses Proliferation by Inducing Cellular Senescence in Pancreatic Cancer. Ann Surg Oncol 2022 Apr 10 1
146 35421634 BAK plays a key role in A-1331852-induced apoptosis in senescent chondrocytes. Biochem Biophys Res Commun 2022 Jun 18 1
147 35468881 JMJD2C mediates the MDM2/p53/IL5RA axis to promote CDDP resistance in uveal melanoma. Cell Death Discov 2022 Apr 25 4
148 35506324 KLF4 prevented angiotensin II-induced smooth muscle cell senescence by enhancing autophagic activity. Eur J Clin Invest 2022 May 4 1