Title : Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury.

Pub. Date : 2019 Jul 8

PMID : 31284268






3 Functional Relationships(s)
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1 In accordance, in a swine model of renal I/R injury, we found the increased expression of Wnt4 and betacatenin correlating with SA-beta Gal, p21, p16 and IL-6 positivity. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid Wnt family member 4 Sus scrofa
2 In accordance, in a swine model of renal I/R injury, we found the increased expression of Wnt4 and betacatenin correlating with SA-beta Gal, p21, p16 and IL-6 positivity. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid catenin beta 1 Sus scrofa
3 Administration of Complement Inhibitor (C1-Inh), antagonized SASP by reducing SA-beta Gal, p21, p16, IL-6 and abrogating Wnt4/betacatenin activation.Thus, C5a affects the DNA methylation of genes involved in tubular senescence. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid serpin family G member 1 Sus scrofa