Title : Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts.

Pub. Date : 2022 Apr 4

PMID : 35378512






3 Functional Relationships(s)
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1 Incubation of MEFs with IGFBP5 during serial passage increased the cumulative population doubling and decreased SA-beta-GAL positivity compared with those in vehicle-treated cells. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid insulin-like growth factor binding protein 5 Mus musculus
2 Silencing of ERK2, but not that of ERK1, blocked the increase in the number of SA-beta-GAL-positive cells in IGFBP5-knockdown cells. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid mitogen-activated protein kinase 1 Mus musculus
3 Silencing of ERK2, but not that of ERK1, blocked the increase in the number of SA-beta-GAL-positive cells in IGFBP5-knockdown cells. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid insulin-like growth factor binding protein 5 Mus musculus