Title : OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.

Pub. Date : 2020

PMID : 33144900






1 Functional Relationships(s)
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1 The effects of OPN siRNA on the SA-beta-Gal expressions and the percentage of apoptotic chondrocytes were examined by using SA-beta-Gal staining and apoptosis assay, and the effects on the expressions of COL2A1 and OA-associated genes (COL10A1, IL-1beta, TNF-alpha, MMP-13, and ADAMTS5) were examined by western blot analysis and quantitative real-time RT-PCR. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid secreted phosphoprotein 1 Homo sapiens