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| 2 | 11600102 | Intragastric DMXB-A, an alpha7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice. | Biol Psychiatry | 2001 Oct 1 |
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| 3 | 16256952 | Theoretical studies of Alzheimer's disease drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine (GTS-21) and its derivatives. | Biochem Biophys Res Commun | 2005 Dec 16 |
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| 4 | 16551836 | N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine. | J Pharmacol Exp Ther | 2006 Jun |
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| 5 | 17334244 | Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. | Crit Care Med | 2007 Apr |
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| 6 | 17349863 | Schizophrenia and the alpha7 nicotinic acetylcholine receptor. | Int Rev Neurobiol | 2007 |
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| 7 | 17414429 | Stimulation of alpha 7 cholinergic receptors inhibits lipopolysaccharide-induced neutrophil recruitment by a tumor necrosis factor alpha-independent mechanism. | Shock | 2007 Apr |
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| 8 | 17493709 | The consequences of reducing expression of the alpha7 nicotinic receptor by RNA interference and of stimulating its activity with an alpha7 agonist in SH-SY5Y cells indicate that this receptor plays a neuroprotective role in connection with the pathogenesis of Alzheimer's disease. | Neurochem Int | 2007 Nov-Dec |
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| 9 | 17591554 | Synthesis and positron emission tomography studies of C-11-labeled isotopomers and metabolites of GTS-21, a partial alpha7 nicotinic cholinergic agonist drug. | Nucl Med Biol | 2007 Jul |
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| 10 | 17621262 | Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung. | Shock | 2007 Dec |
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| 11 | 18848921 | IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors. | Biochem Biophys Res Commun | 2008 Dec 5 |
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| 12 | 19338581 | Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors. | Br J Pharmacol | 2009 May |
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| 13 | 19576181 | GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation. | Biochem Pharmacol | 2009 Oct 1 |
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| 14 | 19741199 | Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation. | Am J Physiol Cell Physiol | 2009 Nov |
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| 15 | 20211606 | Alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells. | Brain Res | 2010 Apr 30 |
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| 16 | 20353818 | Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats. | Brain Behav Immun | 2010 Aug |
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| 17 | 21771746 | α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced tumour necrosis factor-α production and lung injury. | Br J Anaesth | 2011 Oct |
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| 18 | 22884467 | The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. | J Neuroimmunol | 2012 Oct 15 |
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| 19 | 24664237 | The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function. | Mol Med | 2014 Jun 19 |
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| 20 | 25009619 | GTS-21, an α7-nicotinic acetylcholine receptor agonist, modulates Th1 differentiation in CD4<sup>+</sup> T cells from patients with rheumatoid arthritis. | Exp Ther Med | 2014 Aug |
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| 21 | 25985797 | Cross-talk between α7 nAChR-mediated cholinergic pathway and acylation stimulating protein signaling in 3T3-L1 adipocytes: role of NFκB and STAT3. | Biochem Cell Biol | 2015 Aug |
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| 22 | 26490221 | GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor. | Int Immunopharmacol | 2015 Dec |
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| 23 | 26618987 | EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE. | Shock | 2016 Apr |
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| 24 | 27246725 | MicroRNA-205‑5b inhibits HMGB1 expression in LPS-induced sepsis. | Int J Mol Med | 2016 Jul |
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| 25 | 27529131 | Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting by GTS-21, a Specific Agonist for α7 Nicotinic Acetylcholine Receptors. | Shock | 2017 Jan |
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| 26 | 28082382 | Monocytes primed with GTS-21/α7 nAChR (nicotinic acetylcholine receptor) agonist develop anti-inflammatory memory. | QJM | 2017 Jul 1 |
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| 27 | 28264149 | Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression-like behaviour in C57BL/6J mice. | Br J Pharmacol | 2018 Jun |
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| 28 | 28282360 | An ALPHA7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice. | Shock | 2017 Aug |
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| 29 | 28283678 | Deficiency of α7 nicotinic acetylcholine receptor attenuates bleomycin-induced lung fibrosis in mice. | Mol Med | 2017 Apr |
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| 30 | 28420461 | [α7 nicotinic acetylcholine receptor agonist attenuated the lipopolysaccharide-induced inflammatory response via inhibiting the activation of nuclear factor-ΚB]. | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | 2017 Apr |
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| 31 | 28822039 | Stimulation of nAchRα7 Receptor Inhibits TNF Synthesis and Secretion in Response to LPS Treatment of Mast Cells by Targeting ERK1/2 and TACE Activation. | J Neuroimmune Pharmacol | 2018 Mar |
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| 32 | 28825423 | Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation. | Neuropsychopharmacology | 2018 Feb |
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| 33 | 29114104 | Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors. | Neuropsychopharmacology | 2018 May |
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| 34 | 29118926 | GTS-21 attenuates LPS-induced renal injury via the cholinergic anti-inflammatory pathway in mice. | Am J Transl Res | 2017 |
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| 35 | 29190774 | Activation of the cholinergic anti-inflammatory pathway by GTS-21 attenuates cisplatin-induced acute kidney injury in mice. | PLoS One | 2017 |
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| 36 | 29197398 | Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress. | J Neuroinflammation | 2017 Dec 2 |
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| 37 | 29608552 | GTS-21 Reduces Inflammation in Acute Lung Injury by Regulating M1 Polarization and Function of Alveolar Macrophages. | Shock | 2019 Mar |
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| 38 | 29992246 | α7 Nicotinic Acetylcholine Receptor Regulates the Function and Viability of L Cells. | Endocrinology | 2018 Sep 1 |
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| 39 | 30106431 | α7‑nAchR agonist GTS‑21 reduces radiation‑induced lung injury. | Oncol Rep | 2018 Oct |
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| 40 | 30486874 | The effect of the cholinergic anti-inflammatory pathway on collagen-induced arthritis involves the modulation of dendritic cell differentiation. | Arthritis Res Ther | 2018 Nov 28 |
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| 41 | 30947238 | GTS-21 has cell-specific anti-inflammatory effects independent of α7 nicotinic acetylcholine receptors. | PLoS One | 2019 |
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| 42 | 31214160 | Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4<sup>+</sup> T Cells in the Regulation of T Cell Differentiation. | Front Immunol | 2019 |
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| 43 | 32018068 | GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice. | Cytokine | 2020 Apr |
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| 44 | 32044666 | α7 nAChRs expressed on antigen presenting cells are insensitive to the conventional antagonists α-bungarotoxin and methyllycaconitine. | Int Immunopharmacol | 2020 Apr |
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| 45 | 32086096 | Minireview: Divergent roles of α7 nicotinic acetylcholine receptors expressed on antigen-presenting cells and CD4<sup>+</sup> T cells in the regulation of T cell differentiation. | Int Immunopharmacol | 2020 Feb 18 |
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| 46 | 32387130 | GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function. | Immunobiology | 2020 May |
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| 47 | 32600307 | The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation. | Mol Med | 2020 Jun 29 |
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| 48 | 33126860 | The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function. | Mol Med | 2020 Oct 30 |
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| 49 | 33414508 | Vagal-α7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection. | Acta Pharmacol Sin | 2021 Oct |
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| 50 | 33815099 | Activation of the Cholinergic Anti-inflammatory Pathway Attenuated Angiotension II-Dependent Hypertension and Renal Injury. | Front Pharmacol | 2021 |
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