Title : Stimulation of nAchRα7 Receptor Inhibits TNF Synthesis and Secretion in Response to LPS Treatment of Mast Cells by Targeting ERK1/2 and TACE Activation.

Pub. Date : 2018 Mar

PMID : 28822039






3 Functional Relationships(s)
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1 Here we report that the nAchRalpha7 receptor specific agonist GTS-21 inhibits TLR4-induced secretion of preformed TNF from MCs in vivo and in vitro. 3-(2,4-dimethoxybenzylidene)anabaseine toll like receptor 4 Homo sapiens
2 Here we report that the nAchRalpha7 receptor specific agonist GTS-21 inhibits TLR4-induced secretion of preformed TNF from MCs in vivo and in vitro. 3-(2,4-dimethoxybenzylidene)anabaseine tumor necrosis factor Homo sapiens
3 Main inhibitory actions of GTS-21 were prevented by AG490, an inhibitor of JAK-2 kinase. 3-(2,4-dimethoxybenzylidene)anabaseine Janus kinase 2 Homo sapiens