Title : IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors.

Pub. Date : 2008 Dec 5

PMID : 18848921






2 Functional Relationships(s)
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1 Pretreatment with non-specific nAChRs agonists, acetylcholine, nicotine and epibatidine and a specific alpha7 subunit agonist GTS-21 significantly inhibited antigen-induced degranulation of mBMMCs in a dose-dependent manner and GTS-21-induced inhibition was significantly blocked by alpha7 subunit antagonist, alpha-bungarotoxin. 3-(2,4-dimethoxybenzylidene)anabaseine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Pretreatment with non-specific nAChRs agonists, acetylcholine, nicotine and epibatidine and a specific alpha7 subunit agonist GTS-21 significantly inhibited antigen-induced degranulation of mBMMCs in a dose-dependent manner and GTS-21-induced inhibition was significantly blocked by alpha7 subunit antagonist, alpha-bungarotoxin. 3-(2,4-dimethoxybenzylidene)anabaseine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus