Pub. Date : 2020 Oct 30
PMID : 33126860
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to determine whether GTS-21 (3-(2,4-dimethoxybenzylidene) anabaseine), an alpha7 nicotinic acetylcholine receptor (alpha7nAChR) agonist, could (1) inhibit hyperoxia-induced HMGB1 release into the airways; (2) enhance macrophage phagocytosis and (3) increase bacterial clearance from the lungs in a mouse model of ventilator-associated pneumonia. | 3-(2,4-dimethoxybenzylidene)anabaseine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | The aim of this study was to determine whether GTS-21 (3-(2,4-dimethoxybenzylidene) anabaseine), an alpha7 nicotinic acetylcholine receptor (alpha7nAChR) agonist, could (1) inhibit hyperoxia-induced HMGB1 release into the airways; (2) enhance macrophage phagocytosis and (3) increase bacterial clearance from the lungs in a mouse model of ventilator-associated pneumonia. | 3-(2,4-dimethoxybenzylidene)anabaseine | high mobility group box 1 | Mus musculus |
| 3 | of GTS-21 significantly increased bacterial clearance, decreased acute lung injury and decreased accumulation of airway HMGB1 compared to the saline control. | 3-(2,4-dimethoxybenzylidene)anabaseine | high mobility group box 1 | Mus musculus |
| 4 | In addition, GTS-21 significantly inhibited the cytoplasmic translocation and release of HMGB1 from RAW 264.7 cells and attenuated hyperoxia-induced NF-kappaB activation in macrophages and mouse lungs exposed to hyperoxia and infected with PA. | 3-(2,4-dimethoxybenzylidene)anabaseine | high mobility group box 1 | Mus musculus |
| 5 | In addition, GTS-21 significantly inhibited the cytoplasmic translocation and release of HMGB1 from RAW 264.7 cells and attenuated hyperoxia-induced NF-kappaB activation in macrophages and mouse lungs exposed to hyperoxia and infected with PA. | 3-(2,4-dimethoxybenzylidene)anabaseine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 6 | CONCLUSIONS: Our results indicate that GTS-21 is efficacious in improving bacterial clearance and reducing acute lung injury via enhancing macrophage function by inhibiting the release of nuclear HMGB1. | 3-(2,4-dimethoxybenzylidene)anabaseine | high mobility group box 1 | Mus musculus |