Pub. Date : 2017 Mar 14
PMID : 28335434
24 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e., MCF7 and MDA-MB-468). | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e., MCF7 and MDA-MB-468). | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e., MCF7 and MDA-MB-468). | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e., MCF7 and MDA-MB-468). | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e., MCF7 and MDA-MB-468). | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 6 | We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e., MCF7 and MDA-MB-468). | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 7 | FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities. | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 8 | FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities. | flavokawain A | cyclin dependent kinase 1 | Homo sapiens |
| 9 | FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities. | flavokawain A | cell division cycle 25C | Homo sapiens |
| 10 | FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities. | flavokawain A | myelin transcription factor 1 | Homo sapiens |
| 11 | FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities. | flavokawain A | WEE1 G2 checkpoint kinase | Homo sapiens |
| 12 | FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities. | flavokawain A | cyclin dependent kinase 1 | Homo sapiens |
| 13 | In addition, FKA induces apoptosis in SKBR3 cells by increasing the protein expression of Bim and BAX and decreasing expression of Bcl2, BclX/L, XIAP, and survivin. | flavokawain A | BCL2 like 11 | Homo sapiens |
| 14 | In addition, FKA induces apoptosis in SKBR3 cells by increasing the protein expression of Bim and BAX and decreasing expression of Bcl2, BclX/L, XIAP, and survivin. | flavokawain A | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 15 | In addition, FKA induces apoptosis in SKBR3 cells by increasing the protein expression of Bim and BAX and decreasing expression of Bcl2, BclX/L, XIAP, and survivin. | flavokawain A | BCL2 apoptosis regulator | Homo sapiens |
| 16 | In addition, FKA induces apoptosis in SKBR3 cells by increasing the protein expression of Bim and BAX and decreasing expression of Bcl2, BclX/L, XIAP, and survivin. | flavokawain A | BCL2 like 1 | Homo sapiens |
| 17 | In addition, FKA induces apoptosis in SKBR3 cells by increasing the protein expression of Bim and BAX and decreasing expression of Bcl2, BclX/L, XIAP, and survivin. | flavokawain A | X-linked inhibitor of apoptosis | Homo sapiens |
| 18 | FKA also downregulates the protein expression of HER-2 and inhibits AKT phosphorylation. | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 19 | Herceptin plus FKA treatment leads to an enhanced growth inhibitory effect on HER-2 overexpressing breast cancer cell lines through downregulation of Myt1, Wee1, Skp2, survivin, and XIAP. | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 20 | Herceptin plus FKA treatment leads to an enhanced growth inhibitory effect on HER-2 overexpressing breast cancer cell lines through downregulation of Myt1, Wee1, Skp2, survivin, and XIAP. | flavokawain A | myelin transcription factor 1 | Homo sapiens |
| 21 | Herceptin plus FKA treatment leads to an enhanced growth inhibitory effect on HER-2 overexpressing breast cancer cell lines through downregulation of Myt1, Wee1, Skp2, survivin, and XIAP. | flavokawain A | WEE1 G2 checkpoint kinase | Homo sapiens |
| 22 | Herceptin plus FKA treatment leads to an enhanced growth inhibitory effect on HER-2 overexpressing breast cancer cell lines through downregulation of Myt1, Wee1, Skp2, survivin, and XIAP. | flavokawain A | S-phase kinase associated protein 2 | Homo sapiens |
| 23 | Herceptin plus FKA treatment leads to an enhanced growth inhibitory effect on HER-2 overexpressing breast cancer cell lines through downregulation of Myt1, Wee1, Skp2, survivin, and XIAP. | flavokawain A | X-linked inhibitor of apoptosis | Homo sapiens |
| 24 | Our results suggest FKA as a promising and novel apoptosis inducer and G2 blocking agent that, in combination with Herceptin, enhances for the treatment of HER2-overexpressing breast cancer. | flavokawain A | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |