CPRiL

XIAP

X-linked inhibitor of apoptosis

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

• E3 ubiquitin-protein ligase XIAP
• IAP-like protein 1
• RING-type E3 ubiquitin transferase XIAP
X-linked IAP
X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
baculoviral IAP repeat-containing protein 4
inhibitor of apoptosis protein 3
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3