Protein Name X-linked inhibitor of apoptosis
Organism Homo sapiens
Gene ID 331
Gene Symbol


UniProt P98170 (XIAP_HUMAN), B2R9R2 (B2R9R2_HUMAN)
Relationships Total Number of functionally related compound(s) : 647
Total Number of Articles : 934

X-linked inhibitor of apoptosis

Gene Summary

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

  • E3 ubiquitin-protein ligase XIAP
  • IAP-like protein 1
  • RING-type E3 ubiquitin transferase XIAP
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