abiraterone

cytochrome P450 family 17 subfamily A member 1 ; Homo sapiens







113 Article(s)
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101 21807635 Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. 2011 Sep 15 2
102 21868758 Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. 2011 Oct 15 4
103 20159824 Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy. 2010 Mar 20 1
104 20399458 A phase I clinical study of high dose ketoconazole plus weekly docetaxel for metastatic castration resistant prostate cancer. 2010 Jun 1
105 20550118 Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. 2010 Jul 8 1
106 20595043 Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. 2010 Jul 30 1
107 20684610 Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. 2010 Aug 12 1
108 19111799 The Coffey Lecture: steroidogenic enzyme inhibitors and hormone dependent cancer. 2009 Jan-Feb 1
109 19211174 Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls. 2009 Jul 1
110 19223900 CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer. 2009 Mar 10 1
111 19733987 Beyond castration and chemotherapy: novel approaches to targeting androgen-driven pathways. 2009 Oct 20 1
112 18672868 Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer. 2008 Aug 28 2
113 18985049 CYP17 inhibition as a hormonal strategy for prostate cancer. 2008 Nov 1