Title : Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy.

Pub. Date : 2010 Mar 20

PMID : 20159824






1 Functional Relationships(s)
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1 PURPOSE: Abiraterone acetate is a prodrug of abiraterone, a selective inhibitor of CYP17, the enzyme catalyst for two essential steps in androgen biosynthesis. abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens