Title : Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.

Pub. Date : 2009 Jul

PMID : 19211174






1 Functional Relationships(s)
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1 Recently, the steroidal CYP17 inhibitor Abiraterone entered phase II clinical trial for the treatment of androgen-dependent prostate cancer. abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens