Title : Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.

Pub. Date : 2010 Jul 8

PMID : 20550118






1 Functional Relationships(s)
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1 Introduction of isopropylidene substituents onto the linker of biphenylmethylene 4-pyridines resulted in several strong CYP17 inhibitors, which were more potent and selective, regarding CYP 11B1, 11B2, 19 and 3A4, than the drug candidate abiraterone. abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens