| 101 |
24443939 | Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase. | 2014 Jan 21 |
4 |
| 102 |
24549829 | Unbinding free energy of acetylcholinesterase bound oxime drugs along the gorge pathway from metadynamics-umbrella sampling investigation. | 2014 Sep |
1 |
| 103 |
24599312 | Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases. | 2014 Apr 18 |
1 |
| 104 |
24964273 | Can hydroxylamine be a more potent nucleophile for the reactivation of tabun-inhibited AChE than prototype oxime drugs? An answer derived from quantum chemical and steered molecular dynamics studies. | 2014 Jul 29 |
1 |
| 105 |
25190468 | Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties. | 2014 Oct 1 |
2 |
| 106 |
25218671 | Quantum chemical and steered molecular dynamics studies for one pot solution to reactivate aged acetylcholinesterase with alkylator oxime. | 2014 Nov 5 |
6 |
| 107 |
25240274 | Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications. | 2014 Nov 18 |
1 |
| 108 |
25479380 | QSAR Models for the Reactivation of Sarin Inhibited AChE by Quaternary Pyridinium Oximes Based on Monte Carlo Method. | 2014 Nov 26 |
1 |
| 109 |
22827894 | Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes. | 2013 Mar 25 |
6 |
| 110 |
22960624 | Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. | 2013 Mar 25 |
2 |
| 111 |
22975155 | Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates. | 2013 Mar 25 |
1 |
| 112 |
22982773 | A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds. | 2013 Mar 25 |
11 |
| 113 |
23047024 | The cholinergic and non-cholinergic effects of organophosphates and oximes in cultured human myoblasts. | 2013 Mar 25 |
1 |
| 114 |
23073172 | Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model. | 2013 Mar 25 |
2 |
| 115 |
23111374 | Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents. | 2013 Mar 25 |
2 |
| 116 |
23176543 | Toxicological considerations of acetylcholinesterase reactivators. | 2013 Jan |
3 |
| 117 |
23339663 | Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry. | 2013 Feb 18 |
1 |
| 118 |
23410111 | Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agents. | 2013 Mar 1 |
1 |
| 119 |
23534424 | LC-MS/MS approaches for the assay of bis-quaternary pyridinium oximes used as AChE reactivators in biological matrices. | 2013 Apr |
1 |
| 120 |
23735753 | Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage. | 2013 Sep 5 |
1 |
| 121 |
23789829 | In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators. | 2013 Sep |
3 |
| 122 |
23959117 | Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study. | 2013 Aug 16 |
4 |
| 123 |
23962483 | Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates. | 2013 Dec 5 |
2 |
| 124 |
24157926 | Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length. | 2013 Dec 5 |
1 |
| 125 |
24312449 | In silico studies in probing the role of kinetic and structural effects of different drugs for the reactivation of tabun-inhibited AChE. | 2013 |
2 |
| 126 |
21998030 | Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning. | 2012 Mar-Apr |
1 |
| 127 |
22230262 | Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase. | 2012 Mar 7 |
4 |
| 128 |
22309910 | Discovery of non-oxime reactivators using an in silico pharmacophore model of oxime reactivators of OP-inhibited acetylcholinesterase. | 2012 Mar |
3 |
| 129 |
22343626 | Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. | 2012 Apr 6 |
1 |
| 130 |
22360668 | Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings. | 2012 Jan |
3 |
| 131 |
22437842 | Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase. | 2012 Sep |
3 |
| 132 |
22447833 | Cytotoxicity and genotoxicity evaluation of antidote oxime HI-6 tested on eight cell lines of human and rodent origin. | 2012 Mar |
1 |
| 133 |
22561105 | Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase. | 2012 Jul 7 |
3 |
| 134 |
22649796 | Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships. | 2012 Jun 15 |
5 |
| 135 |
22703537 | Effect of different oximes on rat and human cholinesterases inhibited by methamidophos: a comparative in vitro and in silico study. | 2012 Dec |
1 |
| 136 |
22731788 | First principles calculations of thermodynamics and kinetic parameters and molecular dynamics simulations of acetylcholinesterase reactivators: can mouse data provide new insights into humans? | 2012 |
1 |
| 137 |
22808117 | Energetics of Ortho-7 (oxime drug) translocation through the active-site gorge of tabun conjugated acetylcholinesterase. | 2012 |
2 |
| 138 |
20688148 | In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers. | 2011 Feb |
2 |
| 139 |
20807085 | Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach. | 2011 Jun |
4 |
| 140 |
20971170 | Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase. | 2011 Jan 15 |
2 |
| 141 |
21112787 | Peripheral site ligand-oxime conjugates: A novel concept towards reactivation of nerve agent-inhibited human acetylcholinesterase. | 2011 Jan 1 |
1 |
| 142 |
21328273 | Oximes for acute organophosphate pesticide poisoning. | 2011 Feb 16 |
1 |
| 143 |
21402092 | Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro. | 2011 May 15 |
2 |
| 144 |
21464125 | New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases. | 2011 Jun 3 |
2 |
| 145 |
21493754 | Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. | 2011 Jul |
1 |
| 146 |
21504785 | Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase. | 2011 Sep 25 |
2 |
| 147 |
21605992 | Probing the reactivation process of sarin-inhibited acetylcholinesterase with α-nucleophiles: hydroxylamine anion is predicted to be a better antidote with DFT calculations. | 2011 Aug |
1 |
| 148 |
21673941 | In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase. | 2011 |
3 |
| 149 |
21723318 | Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice. | 2011 Dec |
1 |
| 150 |
21726608 | HI 6 human serum albumin nanoparticles--development and transport over an in vitro blood-brain barrier model. | 2011 Sep 25 |
3 |