Pub. Date : 2012 Jun 15
PMID : 22649796
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, numerous in vitro and in vivo studies demonstrated a limited ability of these oximes to reactivate acetylcholinesterase (AChE) inhibited by different OP pesticides and nerve agents. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | However, numerous in vitro and in vivo studies demonstrated a limited ability of these oximes to reactivate acetylcholinesterase (AChE) inhibited by different OP pesticides and nerve agents. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | New oximes were mostly tested for their therapeutic efficacy by using different animal models and for their reactivating potency with AChE from different species. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Now, we found it tempting to determine the reactivation kinetics of a series of bispyridinium oximes bearing one or two oxime groups at different positions and having an oxybismethylene or a trimethylene linker under identical conditions with human AChE inhibited by structurally different OP. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | Hence, these and previous data emphasize the necessity for thorough kinetic investigations of OP-oxime-AChE interactions and underline the difficulty to develop a broad spectrum oxime reactivator which is efficient against structurally different OP inhibitors. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |